Guanidino compounds as melanocortin-4 receptor (mc4-r) agonists

A compound of formula ** ** wherein X and Y are independently selected from the group consisting of N select, C = O, NR9, O, S, (CR6R7) n and C (= O) - (CR6R7) n; n is 1, 2 or 3; wherein when X is N, then Y is not N, provided that when X is N, then Y can still be NH; wherein when Y is N, then X is not N, provided that when Y is N, then X can still be NH; wherein when X is CH2, then Y is not CH2; wherein when X is NH, then Y is not NH; D is selected from the group consisting of N, CH and C; L is NH, O, C (O) NHC (O), OC (O) or a covalent bond; W is selected from the group consisting of Z1, Z2 and Z3 are independently selected from the group consisting of CR8 and N; R1 is selected from the group consisting of arylalkyl, heteroarylalkyl, aryl, heteroaryl, heterocyclyl, cycloalkyl, heterocyclylalkyl, cycloalkylalkyl, alkenyl, alkynyl and substituted and unsubstituted alkyl; R2 is H; R3 is selected from the group consisting of alkyl, alkenyl, alkynyl, cycloalkyl, heteroaryl, heterocyclyl, heterocyclylalkyl, arylalkyl, heteroarylalkyl and cycloalkylalkyl substituted and unsubstituted, or R2 and R3 may be joined to form a ring containing at least two atoms N.