Progesterone receptor modulators having an increased antigonadotropic activity for use in female fertility testing and hormone replacement therapy
Abstract
Use of compounds of the general formula I *** in which R1, R2, R3, R4 and R5 and R15 and R16 radicals have the following meanings: R1 is a hydrogen atom, alkanoyl radical with 1 to 10 atoms carbon or a benzoyl radical optionally substituted with 6-10 carbon atoms or CONHR 5 radical, R5 is a hydrogen atom, an alkyl or acyl radical each having 1-10 carbon atoms or an alkylaryl or aralkyl radical each case 6 to 10 carbon atoms, R 2 represents a hydrogen atom, a halogen atom or a CF 3 group, R3 means a hydrogen atom or CH 2 X group wherein X represents a hydrogen atom, a hydroxy , a halogen atom, an alkyl radical having 1 or 2 carbon atoms, a radical (CH2) nCH2Y with n = 0 or 1 and Y represents a halogen atom, it being possible, when R2 is a halogen atom, R3 can CnFmHo further mean a group, it means a hydrogen atom, n = 1, 2, 3, 4 or 5, m> 1 and m + o = 2n + 1 alkyl or alkanoyl R4 in each case based radical 1- 10 carbon atoms or benzoyl radical with 6-10 carbon atoms or a radical - CONHR 5, possessing the abovementioned meaning R5, R15 and R16 represent hydrogen atoms or together are a double bond, and pharmaceutically acceptable salts, for the preparation of medicaments for the treatment of dysfunctional bleeding.
Term
No projected expiry on record.
- Priority
- Filed
- Granted
- Today
14 members in 10 offices
Priority claims2
| Document | Office | Kind | Date |
|---|---|---|---|
| 10236405 | Germany | A | |
| 40006502 | United States of America | P |
Members14
| Document | Office | Kind | |
|---|---|---|---|
| DE10236405A1 | Germany | A1 | |
| WO2004014935A1 | World Intellectual Property Organization (WIPO) | A1 | |
| AU2003255355A1 | Australia | A1 | |
| US2005026891A1 | United States of America | A1 | |
| EP1525215A1 | European Patent Office (EPO) | A1 | |
| JP2005539016A | Japan | A | |
| EP1525215B1 | European Patent Office (EPO) | B1 | |
| AT338763TThis record | Austria | T | |
| ATE338763T1 | Austria | T1 | |
| DE50304970D1 | Germany | D1 | |
| DK1525215T3 | Denmark | T3 | |
| PT1525215E | Portugal | E | |
| ES2273061T3 | Spain | T3 | |
| US7550451B2 | United States of America | B2 |
2 legal events, as the office reported them to INPADOC
Over the term
Point at a mark for the eventEvents
| Event | Code | |
|---|---|---|
| Ceased due to non-payment of the annual feeCeasedREN | REN | |
| Change of the company nameEEFA | EEFA |
Numbers
- Application
- 3784154
Titles2
- German
- PROGESTERONREZEPTORMODULATOREN MIT ERHÖHTER ANTIGONADOTROPER AKTIVITÄT FÜR DIE WEIBLICHE FERTILITÄTSKONTROLLE UND HORMONERSATZTHERAPIE
- English
- PROGESTERONE RECEPTOR MODULATORS WITH INCREASED ANTIGONADOTROPIC ACTIVITY FOR THE FEMININE FERTILITY CONTROL AND HORMONE RESPONSE THERAPY
Classification
- CPC, 6
- C07J41/0083
- A61P5/24
- A61P15/00
- A61P15/12
- A61P15/18
- A61P35/00
- IPC, 9
- A61K31 565
- A61K31 567
- A61P15 00
- A61P15 12
- A61P15 18
- A61P35 00
- A61P5 24
- C07J1 00
- C07J41 00