AT338763T

Progesterone receptor modulators having an increased antigonadotropic activity for use in female fertility testing and hormone replacement therapy

Abstract

Use of compounds of the general formula I *** in which R1, R2, R3, R4 and R5 and R15 and R16 radicals have the following meanings: R1 is a hydrogen atom, alkanoyl radical with 1 to 10 atoms carbon or a benzoyl radical optionally substituted with 6-10 carbon atoms or CONHR 5 radical, R5 is a hydrogen atom, an alkyl or acyl radical each having 1-10 carbon atoms or an alkylaryl or aralkyl radical each case 6 to 10 carbon atoms, R 2 represents a hydrogen atom, a halogen atom or a CF 3 group, R3 means a hydrogen atom or CH 2 X group wherein X represents a hydrogen atom, a hydroxy , a halogen atom, an alkyl radical having 1 or 2 carbon atoms, a radical (CH2) nCH2Y with n = 0 or 1 and Y represents a halogen atom, it being possible, when R2 is a halogen atom, R3 can CnFmHo further mean a group, it means a hydrogen atom, n = 1, 2, 3, 4 or 5, m> 1 and m + o = 2n + 1 alkyl or alkanoyl R4 in each case based radical 1- 10 carbon atoms or benzoyl radical with 6-10 carbon atoms or a radical - CONHR 5, possessing the abovementioned meaning R5, R15 and R16 represent hydrogen atoms or together are a double bond, and pharmaceutically acceptable salts, for the preparation of medicaments for the treatment of dysfunctional bleeding.

Term

No projected expiry on record.

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10236405GermanyA
40006502United States of AmericaP

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DE10236405A1GermanyA1
WO2004014935A1World Intellectual Property Organization (WIPO)A1
AU2003255355A1AustraliaA1
US2005026891A1United States of AmericaA1
EP1525215A1European Patent Office (EPO)A1
JP2005539016AJapanA
EP1525215B1European Patent Office (EPO)B1
AT338763TThis recordAustriaT
ATE338763T1AustriaT1
DE50304970D1GermanyD1
DK1525215T3DenmarkT3
PT1525215EPortugalE
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US7550451B2United States of AmericaB2