Process for the production of secondary metabolites

(57) The step to which summary book invention is how to have been improved for producing a secondary metabolism product, and this method ferments the microbe which can produce the i above-mentioned secondary metabolism product, ii) It is related with the method characterized by including the step which collects the above-mentioned metabolic products in a pure form substantially. Thereby, the above-mentioned microbe is changed in relation to the biosynthetic pathway of the above-mentioned secondary metabolism product by the style controlled by differing in peptide, protein, or enzyme which blocks it from control of the above-mentioned DNA arrangement in / in revelation of one or more DNA arrangement / a prototypal microbe which carries out a code. Furthermore, a secondary metabolism product is taken into consideration by the microbe and the last which can produce the method for producing the above-mentioned microbe, a DNA structure, a vector or transformation ビヒクル, and a secondary metabolism product.