Adenovirus vectors specific for cells expressing androgen receptor and methods of use thereof

(57) The cell (for example, cell which reveals an androgen receptor (AR)) which enables a summary pro バシン transfer response element (PB-TRE) to function is provided with a specific duplicate competent adenovirus vector and the directions for such a virus. This transcriptional control portion of these viruses is dependence in order at AR revelation including the adenovirus gene under control of a PB-TRE transcriptional control portion. For example, this gene may be a gene needed for virus reproduction, or an adenovirus death protein gene (ADP). This virus may contain again at least one further adenovirus gene under at least one further prostate gland specific transcription response element (for example, element (PSA-TRE) which controls prostate gland specific antigen revelation) control. Therefore, virus reproduction may be restricted to the target cell (especially prostate cancer cells) which shows prostate gland specific gene expression. The adenovirus of the present invention may contain further the heterologous genes (for example, reporter) under PB-TRE transfer control. This adenovirus vector is used, a sample can be detected and monitored about existence of a prostate cell, and the malignant cell which generates a prostate gland specific gene product can be killed and wounded alternatively.