Homogeneous detection method for the determination of sub-populations of an analyte

The invention relates to a method for determining an analyte in a test liquid, where the test liquid is incubated with (A) a first receptor, which binds to a first THIS Epitope ONCE ON ANALYTE AND is immobilized on a particulate support material and (B) a second receptor, which binds to a second epitope of the analyte and which has at least two binding sites FOR THE SECOND epitope, wherein the first epitope being different from the second epitope, detecting The analyte for binding to both receptors.