An osteointegrative interface for implantable prostheses and method for its manufacture

osteointegrative biomimetic interface comprising a substrate (3) of biocompatible material such as titanium, tantalum or alloys thereof, characterized in that it comprises, on the surface (3bis) of the substrate (3), a first layer (4) having a first concentration of oxide biocompatible material, enriched with a second concentration of phosphorus and with a third concentration of calcium, the ratio between the concentration of calcium and phosphorus concentration greater than two, further comprising the biomimetic osteointegrative interface (1) a second layer ( 5) having a first surface (10) in contact with the first layer (4), and a second surface (11), the second layer (5) a fourth concentration of oxide enriched with a fifth concentration of calcium and a sixth phosphorus concentration, being the fourth lower concentration than the fifth and sixth concentrations and the ratio between the fifth concentration of calcium and the sixth phosphorus concentration of not less than three.