Methods and compositions for treatment of cell proliferative disorders

The invention relates to methods and compositions, and compositions at least comprises a endothelin antagonist, the is preferably designed with is β -1,4-N- acetyl glucosamine (p-GlcNAc) polysaccharide matrix combined to the other cancers and hyperphasia diseases' compositions. The endothelin antagonists can be peptide And Huo non-peptide compounds, the p-GlcNA in the invention comprises a macromolecular weight polymer, wherein monosaccharide component is β -1,4 are connected, and are monosaccharide and) respectively comprises a protein, basically and a single amino acid, does not contain the organic and inorganic discharging. The compositions and methods of the invention can be used for inhibiting the growth of the tumours and lump cells, and/or a restraining body lump the transfusion.