AT277044T

Heterocyclic compounds useful as inhibitors of tyrosine kinases

Abstract

A compound of formula (I): ** (Formula) ** wherein: Ar1 is a carbocyclic, heteroaryl or heterocyclic aromatic or nonaromatic; wherein said carbocyclic, heteroaryl or heterocyclic group is optionally substituted by one or more of the R1, R2 groups, and R3; X is NH, N-C1-3 alkyl, N-cyclopropyl, S atom or O atom; Y is a NR15 group, an S atom or an O atom; Ra is a át omo H, C1-10 alkyl group, C2-10 alkenyl group or C2-10 alkynyl group, each of which may be branched or cyclic; or Ra is a group aryl or heteroaryl; wherein each Ra is independently optionally substituted with one or more C1-6 alkyl groups, C1-6 alkoxy, halogen, OH, oxo, NR10R11, aryl or heteroaryl, each aryl or heteroaryl being optionally substituted with one or more groups selected from halogen, OH, C1-3 alkyl, C1-3 alkoxy, hydroxy-C1-3 alkyl, and (CH2) mNR10R11; and wherein Ra is attached wing position 4 or 5; R1 and R2 are the same or different and are selected from an H atom, a halogen atom, CN group, a NO2 group, a C1-10 alkyl group, branched or unbranched, saturated or unsaturated alkoxy group C1-10, branched or unbranched, C1-10 acyl group, branched or unbranched, C1-10 acyloxy group, branched or unbranched alkyl group branched or unbranched C1-10-thio, an aminosulfonyl group, a C1-3 dialkyl-aminosulfonyl group, one NR10R11 group, an aryl group, an aroyl group, an aryloxy group, an arylsulfonyl group, a heteroaryl group and a heteroaryloxy group; in which the R1 and R2 groups are optionally partially above or fully halogenated or optionally substituted with one to three groups independently selected from oxo, OH, NR10R11, C1-6 alkyl branched or unbranched, C3-7 cycloalkyl , phenyl, naphthyl, heteroaryl, aminocarbonyl and mono- or dialkyl-aminocarbonyl C1-3; R3 is a hydrogen atom, a halogen atom, an OH group, a group (CH2) nNR10R11 a CONR10R11 group, (CH2) nCO2R12; C1-3 alkyl group optionally substituted with an OH group, a C1-3 alkoxy group optionally halogenated or a group C1-3 alkyl-thio; R4 and R5 together with the atoms to which they are attached complete a fused ring system of the formulas A or B: ** (Formula) ** R6 is a C1-3 alkyl group or H atom; R7 is a C1-6 alkyl group branched or unbranched, or an atom H.

Term

No projected expiry on record.

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15792299United States of AmericaP
0027444United States of AmericaW

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CA2384378A1CanadaA1
WO0125238A2World Intellectual Property Organization (WIPO)A2
WO0125238A3World Intellectual Property Organization (WIPO)A3
US2002016460A1United States of AmericaA1
EP1222187A2European Patent Office (EPO)A2
MXPA02003364AMexicoA
US6506769B2United States of AmericaB2
US2003166929A1United States of AmericaA1
JP2003527328AJapanA
US6770639B2United States of AmericaB2
EP1222187B1European Patent Office (EPO)B1
AT277044TThis recordAustriaT
ATE277044T1AustriaT1
DE60014130D1GermanyD1
ES2225231T3SpainT3
DE60014130T2GermanyT2
CA2384378CCanadaC
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