Heterocyclic compounds useful as inhibitors of tyrosine kinases
Abstract
A compound of formula (I): ** (Formula) ** wherein: Ar1 is a carbocyclic, heteroaryl or heterocyclic aromatic or nonaromatic; wherein said carbocyclic, heteroaryl or heterocyclic group is optionally substituted by one or more of the R1, R2 groups, and R3; X is NH, N-C1-3 alkyl, N-cyclopropyl, S atom or O atom; Y is a NR15 group, an S atom or an O atom; Ra is a át omo H, C1-10 alkyl group, C2-10 alkenyl group or C2-10 alkynyl group, each of which may be branched or cyclic; or Ra is a group aryl or heteroaryl; wherein each Ra is independently optionally substituted with one or more C1-6 alkyl groups, C1-6 alkoxy, halogen, OH, oxo, NR10R11, aryl or heteroaryl, each aryl or heteroaryl being optionally substituted with one or more groups selected from halogen, OH, C1-3 alkyl, C1-3 alkoxy, hydroxy-C1-3 alkyl, and (CH2) mNR10R11; and wherein Ra is attached wing position 4 or 5; R1 and R2 are the same or different and are selected from an H atom, a halogen atom, CN group, a NO2 group, a C1-10 alkyl group, branched or unbranched, saturated or unsaturated alkoxy group C1-10, branched or unbranched, C1-10 acyl group, branched or unbranched, C1-10 acyloxy group, branched or unbranched alkyl group branched or unbranched C1-10-thio, an aminosulfonyl group, a C1-3 dialkyl-aminosulfonyl group, one NR10R11 group, an aryl group, an aroyl group, an aryloxy group, an arylsulfonyl group, a heteroaryl group and a heteroaryloxy group; in which the R1 and R2 groups are optionally partially above or fully halogenated or optionally substituted with one to three groups independently selected from oxo, OH, NR10R11, C1-6 alkyl branched or unbranched, C3-7 cycloalkyl , phenyl, naphthyl, heteroaryl, aminocarbonyl and mono- or dialkyl-aminocarbonyl C1-3; R3 is a hydrogen atom, a halogen atom, an OH group, a group (CH2) nNR10R11 a CONR10R11 group, (CH2) nCO2R12; C1-3 alkyl group optionally substituted with an OH group, a C1-3 alkoxy group optionally halogenated or a group C1-3 alkyl-thio; R4 and R5 together with the atoms to which they are attached complete a fused ring system of the formulas A or B: ** (Formula) ** R6 is a C1-3 alkyl group or H atom; R7 is a C1-6 alkyl group branched or unbranched, or an atom H.
Term
No projected expiry on record.
- Priority
- Filed
- Granted
- Today
18 members in 9 offices
Priority claims2
| Document | Office | Kind | Date |
|---|---|---|---|
| 15792299 | United States of America | P | |
| 0027444 | United States of America | W |
Members18
| Document | Office | Kind | |
|---|---|---|---|
| CA2384378A1 | Canada | A1 | |
| WO0125238A2 | World Intellectual Property Organization (WIPO) | A2 | |
| WO0125238A3 | World Intellectual Property Organization (WIPO) | A3 | |
| US2002016460A1 | United States of America | A1 | |
| EP1222187A2 | European Patent Office (EPO) | A2 | |
| MXPA02003364A | Mexico | A | |
| US6506769B2 | United States of America | B2 | |
| US2003166929A1 | United States of America | A1 | |
| JP2003527328A | Japan | A | |
| US6770639B2 | United States of America | B2 | |
| EP1222187B1 | European Patent Office (EPO) | B1 | |
| AT277044TThis record | Austria | T | |
| ATE277044T1 | Austria | T1 | |
| DE60014130D1 | Germany | D1 | |
| ES2225231T3 | Spain | T3 | |
| DE60014130T2 | Germany | T2 | |
| CA2384378C | Canada | C | |
| JP5036112B2 | Japan | B2 |
1 legal event, as the office reported them to INPADOC
Events
| Event | Code | |
|---|---|---|
| Publication of translation of european patent specificationUEP | UEP |
Numbers
- Application
- 968713
Titles2
- German
- HETEROCYCLISCHE VERBINDUNGEN VERWENDBAR ALS TYROSINKINASE INHIBITOREN
- English
- HETEROCYCLIC COMPOUNDS USES AS TYROSINE KINASE INHIBITORS
Classification
- CPC, 20
- C07D471/04
- A61P1/04
- C07D217/24
- A61P3/10
- C07D235/30
- A61P9/10
- C07D513/04
- A61P11/06
- A61P17/00
- A61P17/06
- A61P19/02
- A61P19/08
- A61P19/10
- A61P25/28
- A61P29/00
- A61P35/00
- A61P37/02
- A61P37/06
- A61P41/00
- A61P43/00
- IPC, 27
- A61K31 444
- A61K31 4545
- A61K31 4745
- A61K31 496
- A61K31 5377
- A61P1 04
- A61P11 06
- A61P17 00
- A61P17 06
- A61P19 02
- A61P19 08
- A61P19 10
- A61P25 28
- A61P29 00
- A61P3 10
- A61P35 00
- A61P37 02
- A61P37 06
- A61P41 00
- A61P43 00
- A61P9 10
- C07D217 24
- C07D235 30
- C07D471 04
- C07D491 20
- C07D513 04
- C07D519 00