8-quinolinxanthine and 8-isoquinolinxanthine derivatives as pde 5 inhibitors

Free of or salt forms of type (I) compounds, which R1 is hydrogen or any selected to is hydroxy, and n-oxygen base or n-sulfur base replaced of alkyl, R2 is hydrogen, and alkyl, and hydroxy alkyl, and alkyl Carbonyl oxygen base alkyl, and n-oxygen base alkyl, and n-sulfur base alkyl, and chain Ene base, and ring alkyl alkyl, and hybrid ring base alkyl, and Fong alkyl, by in Fong alkyl in the of Fong ring can any selected to and a 5 Yuan hybrid ring group heavy collection or any selected to is a or multiple selected since n-oxygen base, and amino, and alkyl amino, and II alkyl amino, and acyl amino, and halogen, and hydroxy, and Amino sulfonic acyl, and alkyl amino sulfonic acyl, and II alkyl amino sulfonic acyl, and alkyl sulfonic acyl amino or II alkyl amino sulfonic acyl amino of replaced base by replaced, R3 is hydrogen or any selected to is hydroxy, and n-oxygen base or n-sulfur base replaced of alkyl, R4 is hydrogen or alkyl, R5 is quinoline base, and different quinoline base or oxygen generation II hydrogen different quinoline base, these group any selected to and a 5 Yuan hybrid ring group heavy merged and any selected to is a or multiple selected since following of replaced base by replaced: Halogen, and cyanide base, and hydroxy, and alkyl, and hydroxy alkyl, and n-oxygen base alkyl , And n-sulfur base alkyl, and n-oxygen base, and n-sulfur base, and chain vinyl base, and n-oxygen base Carbonyl, and chain acetylene base, and carboxyl, and acyl, and type-N (R6) R7 of group, and any selected to was a or multiple selected since halogen or n-oxygen base of replaced base replaced of aryl, and or by ring carbon Atomic and specifies carbon Atomic connection of contains 5 or 6 a ring Atomic of miscellaneous aryl, R6 and R7 each other independent to is hydrogen or any selected to was hydroxy or n-oxygen base replaced of alkyl, or R6 and R7 in the has a is hydrogen and another is acyl, Or R6 and R7, and together, they are connected to a nitrogen Atom heterocyclic group of 5 or 6.