Method and device for predicting physiological values

A method for measuring continuously or continuously the blood glucose of a subject, said method comprising: (a) obtaining a raw signal from the glucose extracted blood, wherein said raw signal is specifically related to blood glucose; (B) performing a calibration step which correlates the raw signal obtained in step (a) with a measurement value indicative of the concentration of blood glucose present in the subject at the time of extraction; (C) repeating step (a) to obtain a series of measurement values ​​at selected time intervals; and (d) predicting a measurement value based on the series of measurement values ​​using the algorithm Mixtures of Experts, where the individual experts have a linear form (1) wherein (An) is blood glucose , the analyte of interest, n is the number of experts, Ani is the analyte predicted by expert i; and wi is a parameter; and the individual experts Ani are further defined by the expression shown in equation (2) (2) wherein Ani is the analyte predicted by Expert i; Pj is one of m parameters, m is typically less than 100; aij are coefficients; and zi is a constant; and further wherein the weighting value wi is defined by the formula shown in equation (3). (3) where e refers to the exponential function and the dk (note that di in the numerator of Equation 3 is one of the dk) is a parameter set analogous to Equation 2 that is used to determine wi pesos. The dk are given by equation (4). (4) where jk is a coefficient, P j is one of m parameters, and where k is a constant.