Terminally sterilized osteogenic devices and preparation thereof

(57) The last sterilization osteogenic device for transplanting to a summary mammal is indicated. The device is sterilized after combination by exposure to exposure to ionization radiation, for example, a gamma ray, and an electron beam including the combination of biological activity osteogenic protein and an insoluble career. As for the last sterilization device of the present invention, it is the feature that they guide bone formation after transplanting to a mammal. Moreover, the method of guiding bone formation to a mammal is also indicated by transplanting the last sterilization device of the present invention to the position where the mammal was selected beforehand. Moreover, the method of preparing the last sterilization device of the present invention is indicated.