Electrochemical detection of nucleic acid hybridization

Detecting at least comprising a preselected basic groups (e.g. adenine, guanines, 6 - sulfenyl guanines and 8 of the guanines, and 8 of adenine) nucleic acid (e.g DNA. and RNA), the method comprising: a) is the nucleic acid of oxidizing a preselected basic groups in the oxidation reaction a transition metal complex reaction; (b) detects oxidation reaction; A (c) is detecting the oxidation reaction of the preselected basic groups is determined a nucleic acid. The method can be used as more application situations, comprising a DNA sequencing, diagnostic analysis and quantitative analysis.