Monoclonal antibodies recognizing tie-receptor and their use

(57) The new antibody reacted to Tie which is the receptor tyrosine kinase seen by summary epithelial cells and a certain tumor cell group is indicated. An anti-Tie monoclonal antibody is indicated and monoclonal antibody 3C4C7G6 is offered with the hybridoma cell system (DSM ACC2159) which produces the above-mentioned antibody. The above-mentioned antibody is useful as a diagnostic tool for detection of the disease relevant to a neoplastic disease, wound healing, and other various pulse pipe formation including tumor pulse pipe formation, and radiology conversion to signals of a blood vessel. Furthermore, the indicated antibody is useful as a medical treatment agent.