Modified protein and peptide pharmaceuticals

(57) The embellished protein, summary peptide medical-supplies "partial", and a "completeness" CPT unit are used for embellishing this protein and peptide in order to change the pattern of the clearance of bioactive protein and peptide. A "completeness" CPT unit has an amino acid sequence found out by the portions from one of 112*118th of beta subunit of the human Corio gonadotropin to the 145th. At least 1 amino acid is carrying out deficiency of the "partial" CPT unit in the domains from the 118th to the 145th. The mutant of these CPT unit includes 1*5 conservative amino acid substitution which does not destroy the activity. Suitable peptide or protein embellished with this method contains various hormones and cytokine.