Substituted benzoylguanidines, process for their preparation, their use as medicament, as inhibitor of the cellular Na+/H+ exchange or as diagnostic agent and medicament containing them.

(57) Summary composition type I 化 1 (R (1) *R (3) among a formula) H, Hal, アルキル (cyclo), N, CN or OH, アルキルオキシ, The salt which benzoyl guanidine of being phenyl, フェノキシ, or benzoyl and these compounds can permit pharmacologically. Replaced benzoyl guanidine which is shown by (however, compound benzoyl guanidine 4* クロロ benzoyl guanidine, 3, 4* ジクロロ benzoyl guanidine and 3*, or 4* methyl benzoyl guanidine is excluded). This compound -- the compound II -- it is obtained by making 化 2 (the inside of a formula and L are removal machines) react to guanidine. Effect This compound is useful as inhibitor of Na/H exchange of a cell.