Methods for automatically monitoring analyte concentration using minimally invasive devices

Methods and devices are provided to continuously "monitor" the concentration of an analyte in a host, that is, to automatically measure the concentration of an analyte at two or more points over a given period of time. In the methods herein, substantially painless single-use analyte concentration detection devices are employed to measure the concentration of analyte of interest in the host, or portion thereof, eg, interstitial fluid, where measurements are made automatically according to a predetermined planning. The devices provided by the methods herein have at least two substantially different painless single-use analyte concentration measurement components, which are under the control of a processing element that activates the measurement components according to a predetermined schedule. . Provisions and kits are also provided for use when practicing the methods herein. The methods herein have use in monitoring the concentration of a variety of different analytes of interest, and are particularly suitable for use in monitoring the concentration of glucose.