Methods of creating and screening DNA-encoded libraries

The present application provides methods for generating and screening libraries of DNA codes. The present invention features a number of methods for identifying one or more compounds that bind to a biological target. The method includes the synthesis of a library of compounds wherein the compounds contain functional moieties with one or more diverse positions. The functional moiety of the compound is operably linked to the starting oligonucleotide that recognizes the structure of the functional moiety.