Quinolinone derivatives

Organic compounds having the formulas (I) and (II) are provided where the variables have the values described herein. Medicaments include an anti-cancer drug selected from 5-FU or CPT 11 and a compound of formula (I) or formula (II), a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer in treatin along with an anti-cancer drug selected from 5-FU or CPT-11. The medicaments may be used in treating cancer. The use of a compound of formula (I) or formula (II), a tautomer of the compound, a pharmaceutically acceptable salt of the compound, or a pharmaceutically acceptable salt of the tautomer in treating cancer in conjunction with an anti-cancer drug selected from 5-FU or CPT-11 is also provided.